In May 1893, Chicago's World's Fair is in full swing. A young woman arrives in the city to start a new job as an assistant to Dr. H.H. Holmes, but...
Dr. H.H. Holmes designed his entire hotel with murder in mind. Business is thriving - until Holmes is forced to choose between his latest mistress or his wife.
Serial killer Dr. H.H. Holmes racks up quite a body count. When detectives begin closing in, he invents new scams in order to found his finale escape from Chicago.